Scientific articles

Abstract

The effectiveness of intramuscular vaccines aimed at preventing severe COVID-19 remains limited due to waning immunity and the emergence of novel variants. Next-generation vaccines are needed for broader protection and blocking virus transmission. Here, we rationally designed an original nasal subunit vaccine composed of a fusion protein (SwFN) made of Wuhan spike and nucleoprotein combined with biocompatible mucosal nanocarriers (Nc). In mouse model, the nasal Nc-SwFN vaccine elicited multivalent serum and mucosal neutralizing antibodies. Robust spike and nucleoprotein cross-reactive immunity against variants was induced with a predominant phenotype of resident memory T cells in the lungs. Moreover, Nc-SwFN led to protective responses against Wuhan and Delta infection in relevant models with an absence of morbidity, mortality, and virus dissemination in the lungs and brain. Finally, Nc-SwFN drastically reduced host-to-host transmission. These promising results underscore the advantages of the nasal Nc-SwFN approach as a broad-spectrum vaccine candidate against current and emerging SARS-CoV-2 variants.

full-text access : https://rdcu.be/eiiRP

Mathieu EPARDAUD, co-founder, and scientific consultant at Lovaltech, is the author of the article “Advantages and challenges of anti-COVID nsal vaccination: the promises of a French approach“ published on December 19, 2022, in the French version and on February 13, 2023, in the English version on the Conversion.

In this article, Mathieu describes the specific features of the French vaccine against Covid 19, in terms of its administration, mode of operation and manufacturing technique. Mathieu also talks about the next steps in the development of the nasal vaccine, and the challenges facing the Lovaltech team. In particular, the development of a spray system compatible with vaccination. Two methods are presented in this article: an in vitro method and an in vivo method.

French version: https://theconversation.com/atouts-et-defis-de-la-vaccination-nasale-anti-covid-les-promesses-dune-approche-francaise-196529

English version: https://theconversation.com/advantages-and-challenges-of-anti-covid-nasal-vaccination-the-promises-of-a-french-approach-197746